The Science
We’re committed to scientific rigour, investing in independent research and evidence-based development, so you can trust every capsule.
![SPB-in vivo-Microbial Diversity-block-without-CTA](/_next/image/?url=https%3A%2F%2Fimages.ctfassets.net%2Ft51bs9y4c70l%2F6sgbylirEHas6ywVOh4YL7%2F3cd1fdc0239b34298e0ab90fb97d6593%2FGraph_4_rectangle.jpg%3Fq%3D90%26w%3D1000&w=2048&q=75)
Real-life impact
Biotic⁺
We ran an in vivo study to measure the impact of Biotic⁺. This eight-week, placebo-controlled trial studied the well-being, microbiomes, and gut functions of 33 healthy participants.
The results
73% felt better mood*
68% improved perceived health*
92% maintained or increased microbial diversity*
![SHIME in vitro study — SPB mobile](/_next/image/?url=https%3A%2F%2Fimages.ctfassets.net%2Ft51bs9y4c70l%2F4mlOjmr9U6WA5JxDcTsAMd%2Faa1c4826cad5529651c3641c852b9d04%2FMOBILE__2_.jpg%3Fq%3D90%26w%3D1000&w=2048&q=75)
Biotic⁺
We conducted an in vitro study with our independent lab partners ProDigest, who tested the efficacy of Biotic⁺ using their SHIME® (Simulator of Human Intestinal Microbial Ecosystem) model.
The results
33.9bn CFUs reached colon alive
↑ butyrate production
↑ acetate production
↑ propionate production
Ingredient research
Independent studies that support Biotic⁺
Research on three of our favorite strains in Biotic⁺.
CEREBIOME®—B. longum Rosell®-175
Strength of evidence
Strong
Improves digestive health and relieves symptoms of gut discomfort.*
9
No. of studies
1987-2022
Years of studies
CEREBIOME®—L. helveticus Rosell®-52
Strength of evidence
Strong
Reduces stress and supports mental health and emotional balance.*
12
No. of studies
2011-2021
Years of studies
Saccharomyces boulardii
Strength of evidence
Strong
Enhances gut immune function while combating inflammation.*
8
No. of studies
2006-2019
Years of studies
![SS-in vivo-cortisol levels](/_next/image/?url=https%3A%2F%2Fimages.ctfassets.net%2Ft51bs9y4c70l%2F63bT5YybZeSpkssdREM1pb%2F76b345ac4b6fc996b09d0017a3f8fcf5%2FGraph_2_v2.jpg%3Fq%3D90%26w%3D1000&w=2048&q=75)
Everyday effects
Vitals⁺
We wanted to document how Vitals⁺ affects people in their everyday lives. So, in partnership with Citrus Labs, we invested in a 12-week in vivo study of 32 healthy people to quantify its impact.
The results
75% felt better overall
Improved recall
Better focus
Deeper sleep
Ingredient research
Independent studies that support Vitals⁺
Research on three of our favorite nutrients in Vitals⁺.
Omega 3 DHA
Strength of evidence
Strong
Improves cognitive function, including focus, learning, and memory.*
13
No. of studies
2010-2019
Years of studies
Vitamin D3
Strength of evidence
Strong
Promotes a positive mood, and may reduce the risk of anxiety and depression.*
9
No. of studies
2010-2019
Years of studies
Vitamin B12
Strength of evidence
Strong
Boosts energy, while at the same time reducing feelings of tiredness and fatigue.*
8
No. of studies
2008-2019
Years of studies
Developed by scientists.
Latest research. Third-party testing. Cutting-edge technology.
Our team of respected scientists and dietitians never stop working to bring you the results you want. So you can always trust that our supplements lead the way.
![Sophie – Experts](/_next/image/?url=https%3A%2F%2Fimages.ctfassets.net%2Ft51bs9y4c70l%2F2Pbqe7dxv8IUmMmvZzzpNj%2Fb35cc97def88b98cced147fc13f26ffe%2FSPB_efficacy-1.jpg%3Ff%3Dcenter%26fit%3Dfill%26h%3D600%26q%3D90%26w%3D400&w=2048&q=75)
Sophie Medlin, RD
Head of Nutritional Research
Sophie Medlin, RD
Head of Nutritional Research
Our Head of Nutritional Research, a consultant dietitian, chair of the British Dietetic Association for London, and founder of City Dietitians.
![Tara – Experts](/_next/image/?url=https%3A%2F%2Fimages.ctfassets.net%2Ft51bs9y4c70l%2F7fNdDqPc9s2HpNBqp8gfG6%2F1e517abafc6174aba2b9858d97688054%2FSPB_efficacy-2.jpg%3Ff%3Dcenter%26fit%3Dfill%26h%3D600%26q%3D90%26w%3D400&w=2048&q=75)
Dr Tara Swart, PhD
Chief Science Officer
Dr Tara Swart, PhD
Chief Science Officer
An Oxford- trained medical doctor, a neuroscientist with a PhD in neuropharmacology, and a senior lecturer at MIT.